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EFSA's evaluation is related to the risks of TiO₂ used as a food additive, not to other uses.

Overall, the Food Directorate's comprehensive review of the available science of TiO₂ as a food additive showed:

For research published in Archives of Toxicology in 2020, scientists fed one group of mice a solution containing titanium dioxide for one month, and compared it to those that did not receive the additive. They found “the richness and evenness of gut microbiota were remarkably decreased and the gut microbial community compositions were significantly changed” in the titanium dioxide group when compared with the control group. The tests also revealed that the titanium dioxide exposure could cause locomotor dysfunction, or mobility issues “by elevating the excitement of enteric neurons, which might spread to the brain via gut-brain communication by vagal pathway.” The researchers concluded: “These findings provide valuable insights into the novel mechanism of TiO2NP-induced neurotoxicity. Understanding the microbiota-gut-brain axis will provide the foundation for potential therapeutic or prevention approaches against TiO2NP-induced gut and brain-related disorders.”

In addition to hiding power, titanium dioxide also plays a vital role in enhancing the durability of paints. It acts as a barrier, protecting the walls from external elements such as UV radiation, moisture and pollutants. Titanium dioxide's high refractive index allows it to reflect harmful UV rays, preventing them from fading paint and retaining its vibrant colors for a long time. This UV resistance is especially important for facades that are exposed to sunlight throughout the day.

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